Staff & Leadership

Larry Moulton, PhD, MS

Larry Moulton, PhD, MS - Photo


Department of International Health, Bloomberg School of Public Health
The Johns Hopkins University

Research interests

International Health, Biostatistics, Statistical Epidemiology, Longitudinal Data, Bioassay, Cluster Randomized Trials, Vaccine Safety, Vaccine Effectiveness, Vitamin A, HIV/AIDS, Landmines

Methods of expertise

My work in HIV began in the early 1990s when I started working for the Johns Hopkins University as a statistician for HIV epidemiologic studies in Haiti.  Since then, much of my HIV work has been in conjunction with tuberculosis research. I have been the principal statistician where I was involved in all phases of design, conduct, and analysis on a number of HIV and TB related studies (i.e. studies of the 14,000+ mother-infant pairs in the ZVITAMBO project in Zimbabwe, the male circumcision trial in Uganda, and the rifapentine and extended INH prophylaxis studies for HIV-related TB in Soweto).  In addition, I ran the Biostatistics Core of CREATE, a consortium of large TB community-based studies in HIV-endemic areas. My long-time focus on statistical methods for correlated data have led to me being in involved in designing a number of community randomized field trials of HIV-related interventions.

Services available to CFAR investigators

I have extensive experience in helping researchers focus their research concepts, in identifying appropriate methods for sample size calculations, in carrying out balanced randomization schemes, and in providing analytic solutions to complicated data situations.

Sample projects

  1. Hayes, R.J., Moulton, L.H. Cluster Randomised Trials, Boca Raton, CRC Press, 2009. We are revising this for a second edition in 2017. 
  2. Moulton, L.H., Golub, J.E., Durovni, B., Cavalcante, S.C., Pacheco, A.G., Saraceni, V., King, B., Chaisson, R.E. Statistical Design of THRio: a Phased Implementation Clinic-randomized Study of a Tuberculosis Preventive Therapy Intervention.  Clinical Trials, Vol. 4, 190-199, 2007.
  3. Durovni, B., Saraceni, V., Moulton, L.H., Pacheco, A.G., Cavalcante, S.C., King, B.S., Cohn, S., Efron, A., Chaisson, R.E., Golub, J.E. Effect of Improved Tuberculosis Screening and Isoniazid Preventive Therapy on Incidence of Tuberculosis and Death in Patients with HIV in Clinics in Rio de Janeiro, Brazil: a Stepped Wedge, Cluster-randomised Trial. Lancet Infectious Diseases, 2013. Oct;13(10):852-8.
  4. Related talk: "Design and Analysis of a Stepped Wedge Tuberculosis Prevention Study in Brazil" :