Staff & Leadership
Eric Seaberg, PhD
Department of Epidemiology, Bloomberg School of Public Health
The Johns Hopkins University
Epidemiologic methods, cohort studies, case-control studies, nested studies, longitudinal data analysis, survival analysis, HIV/AIDS, chronic disease burden and progression in the context of HIV, viral hepatitis.
Methods of expertise
Dr. Seaberg has both epidemiologic and biostatistical expertise with the design and analysis of studies focusing on the incidence and course of chronic diseases among people infected with HIV. He developed and executed a number of observational cross-sectional, case-control, nested, and cohort studies within the Multicenter AIDS Cohort Study (MACS) and Women’s Interagency HIV Study (WIHS) which are coordinated here in the Bloomberg School of Public Health.
Services available to CFAR investigators
Design and development of research protocols for observational studies, linking investigators with experts in the epidemiology of HIV, mentoring young investigators who are planning and executing epidemiological studies including data management and quality control issues and the interpretation of study findings in the context of HIV literature.
- Sacktor N, Skolasky RL, Seaberg E, Munro C, Becker JT, Martin E, Ragin A, Levine A, Miller E. Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study. Neurology. 2016; 86(4):334-40.
HIV-associated neurocognitive disorder (HAND) progression appears to be limited over a 4 year follow-up period among men taking effective antiretroviral therapy.
- McKibben RA, Haberlen SA, Post WS, Brown TT, Budoff M, Witt MD, Kingsley LA, Palella FJ Jr, Thio CL, Seaberg EC. A Cross-sectional Study of the Association Between Chronic Hepatitis C Virus Infection and Subclinical Coronary Atherosclerosis Among Participants in the Multicenter AIDS Cohort Study. The Journal of infectious diseases. 2016; 213(2):257-65.
Chronic HCV infection is associated with subclinical CVD, suggesting that vigilant assessments of cardiovascular risk are warranted for HCV-infected individuals.
- Seaberg EC, Witt MD, Jacobson LP, Detels R, Rinaldo CR, Young S, Phair JP, Thio CL. Spontaneous Clearance of the Hepatitis C Virus Among Men Who Have Sex With Men. Clin Infect Dis. 2015 Nov 1;61(9):1381-8.
High spontaneous HCV clearance coupled with the lack of an association between the rs12979860 SNP and spontaneous clearance among MSM who do not use injection drugs suggests that the immune mechanisms involved with a successful response to acute HCV differ by mode of virus acquisition.
- Hessol NA, Martínez-Maza O, Levine AM, Morris A, Margolick JB, Cohen MH, Jacobson LP, Seaberg EC. Lung cancer incidence and survival among HIV-infected and uninfected women and men. AIDS. 2015 Jun 19;29(10):1183-93.
Pulmonary damage and inflammation associated with HIV infection may be causally related to an increased risk of lung cancer.
- Matthews GV, Seaberg EC, Avihingsanon A, Bowden S, Dore GJ, Lewin SR, Sasadeusz J, Revill PA, Littlejohn M, Hoy JF, Finlayson R, Ruxrungtham K, Saulynas M, Locarnini S, Thio CL. Patterns and causes of suboptimal response to tenofovir based therapy in HIV-HBV infected individuals. Clin Infect Dis. 2013;56(9):e87-94. doi: 10.1093/cid/cit002.
Combination tenofovir/emtricitabine was superior to other anti-HBV regimens in long-term HBV suppression, and suboptimal adherence was associated with detectable HBV DNA during therapy even when HIV was undetectable.
My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47827067/?sort=date&direction=descending
Multicenter AIDS Cohort Study: http://aidscohortstudy.org/
Women’s Interagency HIV Study: https://statepi.jhsph.edu/wihs/wordpress/